DEVELOPMENT OF A PURIFICATION TECHNOLOGY FOR PHARMACEUTICAL-GRADE SODIUM CARBOXYMETHYL CELLULOSE (NA-CMC) FROM MASHAR STEM CELLULOSE FOR MEDICAL GYPSUM APPLICATIONS
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This study presents a technology for producing highly purified sodium carboxymethyl cellulose (Na-CMC) from cellulose extracted from locally available mashar stems for medical applications, particularly in the manufacture of medical gypsum. Technical Na-CMC was purified by ethanol extraction using a 53% aqueous ethanol solution, and the influence of extraction time on the purity and quality of the final product was systematically investigated. The optimum extraction time was found to be 40 min, resulting in a maximum main substance content of 99%. The physicochemical properties of the purified Na-CMC, including degree of substitution, dynamic viscosity, water solubility, and pH, were determined and compared with the requirements of relevant technical standards. X-ray diffraction (XRD) analysis confirmed the successful structural transformation of cellulose into Na-CMC through a reduction in crystallinity after carboxymethylation. The results demonstrate that mashar stem cellulose is a promising renewable local raw material for the production of pharmaceutical-grade Na-CMC with properties suitable for medical gypsum and other biomedical applications.
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